Biochemistry Reference Ranges: Difference between revisions

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{| class="wikitable"
{| class="wikitable"
|'''BLODD GASES'''
|'''BLODD GASES'''
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|-
|'''This page is under construction'''
|'''Ionised Calcium - corrected (pH 7.4)'''
|'''1.13-1.26'''
|'''1.13-1.26'''
|'''mmol/L'''
|
|-
|'''Chloride'''
|'''95-110'''
|'''95-110'''
|'''mmol/L'''
|
|-
|'''Glucose (random)'''
|'''3.5-7.7'''
|'''3.5-7.7'''
|'''mmol/L'''
|
|-
|'''Lactate'''
|'''<2.0'''
|'''<2.0'''
|'''mmol/L'''
|
|-
|'''Anion Gap'''
|'''10-20'''
|'''10-20'''
|'''mmol/L'''
|
|-
|
|
|
|
|
|-
|'''CORD GASES'''
|'''ARTERIAL'''
|'''VENOUS'''
|'''UNITS'''
|'''COMMENTS'''
|-
|'''pH'''
|'''7.10-7.40'''
|'''7.22-7.44'''
|  
|  
|  
|  
|-
|'''pCO2'''
|'''42-74'''
|'''28-53'''
|'''mmHg'''
|
|-
|'''pO2'''
|'''6-28'''
|'''16-40'''
|'''mmHg'''
|
|-
|'''HCO3'''
|'''18-28'''
|'''17-26'''
|'''mmol/L'''
|
|-
|'''Base Excess'''
|'''-12 to +2'''
|'''-12 to +2'''
|'''mmol/L'''
|
|-
|'''Lactate'''
|'''<6.1'''
|'''<6.1'''
|'''mmol/L'''
|
|}
{| class="wikitable"
|'''Urine'''
|'''SEX/AGE'''
|'''REF RANGE'''
|'''UNITS'''
|'''COMMENTS'''
|-
|'''U Calcium (24hrs)'''
|
|'''2.5-7.5'''
|'''mmol/24hrs'''
|
|-
|'''U Creatinine (24hrs)'''
|'''0-6 months'''
|'''0.2-1.6'''
|'''mmol/24hrs'''
|
|-
|
|'''>6 months - 2 yrs'''
|'''0.2-2.0'''
|'''mmol/24hrs'''
|
|-
|
|'''>2-6 yrs'''
|'''0.5-6.0'''
|'''mmol/24hrs'''
|
|-
|
|'''>6-10 yrs'''
|'''1.5-12.6'''
|'''mmol/24hrs'''
|
|-
|
|'''>10-15 yrs'''
|'''2.0-20.0'''
|'''mmol/24hrs'''
|
|-
|
|'''>15 yrs (male)'''
|'''9.0-18.0'''
|'''mmol/24hrs'''
|
|-
|
|'''>15 yrs (female)'''
|'''7.0-12.5'''
|'''mmol/24hrs'''
|
|-
|'''Creatinine Clearance'''
|
|'''>1.5'''
|'''ml/sec'''
|
|-
|'''U Albumin
|
|'''<30'''
|'''mg/L'''
|
|-
|'''U Alb/Crn Ratio'''
|'''Male'''
|'''<2.5'''
|'''g(alb)/mol(Crn)'''
|
|-
|
|'''Female'''
|'''<3.5'''
|'''g(alb)/mol(Crn)'''
|
|-
|'''U Osmolality'''
|'''0-6 yrs'''
|'''50-1200'''
|'''mosm/kg'''
|
|-
|
|'''>6 yrs'''
|'''300-1200'''
|'''mosm/kg'''
|
|-
|'''U pH'''
|
|'''5-8.8'''
|
|
|-
|'''U Phosphate (24hrs)'''
|
|'''16-48'''
|'''mmol/24hrs'''
|'''dependent on diet, age, muscle mass'''
|-
|'''U Potassium (24hrs)'''
|
|'''35-100'''
|'''mmol/24hrs'''
|'''diet dependent'''
|-
|'''U Protein (24hrs)'''
|
|'''0.0-0.14'''
|'''g/24hrs'''
|
|-
|'''U Pro/Crn Ratio'''
|
|'''<22.7'''
|'''g/mol'''
|
|-
|'''U Sodium (24hrs)'''
|
|'''100-250'''
|'''mmol/24hrs'''
|'''diet dependent'''
|-
|'''U Urea (24hrs)'''
|
|'''165-580'''
|'''mmol/24hrs'''
|
|}
{| class="wikitable"
|'''LIPIDS'''
|'''SEX/AGE'''
|'''REF RANGE'''
|'''UNITS'''
|'''COMMENTS'''
|-
|'''Cholesterol (Total)'''
|
|'''<4.0'''
|'''mmol/L'''
|
|-
|'''HDL Cholesterol'''
|
|'''>1.0'''
|'''mmol/L'''
|
|-
|'''LDL (calculated)'''
|
|'''<2.5'''
|'''mmol/L'''
|
|-
|'''Chol/HDL Ratio'''
|
|'''<4.5'''
|
|
|-
|'''Triglyceride'''
|
|'''<1.7'''
|'''mmol/L'''
|
|}
'''Optimal lipid levels are suggested by the New Zealand Guidelines Group.'''
'''http://www.health.govt.nz/publication/new-zealand-primary-care-handbook-2012'''
{| class="wikitable"
|'''DRUGS'''
|
|'''REF RANGE'''
|'''UNITS'''
|'''COMMENTS'''
|-
|'''Carbamazepine'''
|'''Therapeutic range'''
|'''16-50'''
|'''umol/L'''
|
|-
|'''Digoxin'''
|'''Therapeutic range'''
|'''0.6-2.0'''
|'''nmol/L'''
|'''>6 hrs post-dose'''
|-
|'''Ethanol'''
|'''Nil detected'''
|'''<2.2'''
|'''mmol/L'''
|
|-
|'''Lithium'''
|'''for prophylaxis'''
|'''0.4-0.8'''
|'''mmol/L'''
|
|-
|
|'''for acute mania'''
|'''0.8-1.2'''
|'''mmol/L'''
|
|-
|
|'''toxicity is common'''
|'''>1.2'''
|'''mmol/L'''
|'''>12 hrs post-dose'''
|-
|'''Phenytoin'''
|'''Therapeutic range'''
|'''40-80'''
|'''umol/L'''
|
|-
|'''Salicylate'''
|'''Therapeutic range'''
|'''1.5-1.8'''
|'''mmol/L'''
|
|-
|
|'''Toxic'''
|'''>3.6'''
|'''mmol/L'''
|
|-
|'''Theophylline'''
|'''Therapeutic range'''
|'''55-110'''
|'''umol/L'''
|
|-
|'''Valproate'''
|'''<6 months'''
|'''28-55'''
|'''umol/L'''
|
|-
|  
|  
|
|'''>6 months'''
|'''350-700'''
|'''umol/L'''
|'''not reported but widely accepted as a trough range'''
|}
|}
'''Note: Antibiotics - Gentamicin, Vancomycin and Tobramycin ranges, please refer to Pharmacy for dose and time related reference ranges.'''
'''Reference ranges have been set in agreeance with:'''
'''- The South Island Quality Assurance Group (SIQAG)'''
'''- Chemical Pathology Network New Zealand (CHEMPNNZ)'''
'''- Te Whatu Ora Hawkes Bay Chemical Pathologist'''
'''- Abbott Alinity assay specific reference ranges'''
''' - The LabNet Delphic Partners'''
'''Reference ranges reviewed August 2023'''

Latest revision as of 01:50, 12 September 2023

TEST SEX/AGE REFERENCE RANGE UNITS COMMENTS
AFP 0-16 ug/L
Albumin 0-14 days 28-41 g/L
>14 days - 1 yr 28-45 g/L
>1-8 yrs 35-45 g/L
>8-15 yrs 37-47 g/L
>15 yrs 32-48 g/L
ALP 0-1 yr 60-500 U/L
1-10 yrs 80-360 U/L
11-16 yrs (male) 90-450 U/L
11-16 yrs (female) 80-400 U/L
>16-18 yrs (male) 60-300 U/L
>18 yrs 30-150 U/L
ALT male 0-40 U/L
female 0-30 U/L
Ammonia 0-30 days <50 umol/L
>30 days - Adult 11-32 umol/L
AST <1 month 20-200 U/L
1 month-2 yrs 20-80 U/L
>2-5 yrs 15-60 U/L
>5 yrs 10-50 U/L
bHCG non-pregnant adult <5 IU/L
B12 130-650 pmol/L
grey-zone 130-250 pmol/L
Bicarbonate (HCO3) 22-32 mmol/L
Bilirubin (Direct/Conjugated) 0-5 umol/L
Bilirubin (Total) <24 hrs (cord blood) <50 umol/L
24 hrs (day after birth) <100 umol/L
48 hrs (2 days after birth) <140 umol/L
3 days <200 umol/L
4-14 days <170 umol/L
2-6 weeks 3-23 umol/L
>6 weeks 2-20 umol/L
BNP (NT-proBNP) 0-50 yrs <52 pmol/L
>50-75 yrs <105 pmol/L
>75 yrs <211 pmol/L
CA 125 0-35 kIU/L
CA 153 <30 kIU/L
CA 199 <37 kIU/L
Calcium 2.2-2.6 mmol/L
CEA 0-5 ug/L
Chloride 95-110 mmol/L
CK male 60-220 U/L
female 30-180 U/L
Cortisol random 170-540 nmol/L 0800 diurnal peak
Short Synacthen Test >400 (normal) nmol/L 30min post
Dexamethasone Suppression Test <50 (excludes Cushing's) nmol/L 0800 post dose at 2400hrs
Dexamethasone Suppression Test <50 (excludes Cushing's) nmol/L 0800 post dose at 2400hrs
Creatinine <30 days 20-60 umol/L
>1 month - 2 yrs 20-50 umol/L
>2-4 yrs 20-60 umol/L
>4-6 yrs 25-65 umol/L
>6-10 yrs 25-70 umol/L
>10-15 yrs 40-80 umol/L
>15 yrs (male) 50-110 umol/L
>15 yrs (female) 45-90 umol/L
CRP <5 mg/L
eGFR 80-120 mL/min/1.73m2 GFR declines by 1mL/min/year over age 40 years
Ferritin <15 yrs 15-150 ug/L
>15-30 yrs (male) 20-350 ug/L
>15-50 yrs (female) 20-200 ug/L
>30 yrs (male) 20-500 ug/L
>50 yrs (female) 20-350 ug/L
Folate >8 nmol/L
FSH <10 yrs 0-6.5 IU/L
>10-15 yrs 0-6.5 (pre-pubertal) IU/L levels rise during puberty towards adult range
>15 yrs (female)
Follicular 3-10 IU/L
Mid-Cycle 4-25 IU/L
Luteal 2-8 IU/L
Post-Menopausal >20 IU/L
Antenatal <1 IU/L
Male 2-12 IU/L
GGT <6 months <150 U/L
>6-12 months <50 U/L
>1-12 yrs <30 U/L
>12 yrs (male) 10-50 U/L
>12 yrs (female) 10-35 U/L
Glucose Random 3.5-7.7 mmol/L
Fasting 3.5-6.0 mmol/L
Polycose test <7.8 mmol/L 1hr post
HbA1c Non-diabetic 20-40 mmol/mol
Pre-diabetes 41-49 mmol/mol
Diabetes >49 mmol/mol
IgA <1 yr 0.0-0.3 g/L
1-<3 yrs 0.0-0.9 g/L
3-<6 yrs 0.3-1.5 g/L
6-<14 yrs 0.5-2.2 g/L
14-<19 yrs 0.5-2.9 g/L
Adult 0.4-2.3 g/L
IgG <15 days 3.2-14.0 g/L
15 days - <1 yr 2.0-7.0 g/L
1-<4 yrs 3.2-11.5 g/L
4-<10 yrs 5.4-13.6 g/L
10-<19 yrs 6.6-15.3 g/L
Adult 7.0-16.0 g/L
IgM <15 days 0.1-0.4 g/L
15 days - <13 wks 0.1-0.7 g/L
1-<4 yrs 3.2-11.5 g/L
13 wks - <1 yr 0.2-0.9 g/L
1-<19 yrs 0.4-1.9 g/L
Adult 0.4-2.3 g/L
Iron <2 months 10-31 umol/L
2 months - 1 yr 4-27 umol/L
>1-10 yrs 5-23 umol/L
>10-18 yrs 8-32 umol/L
>18 yrs 10-30 umol/L
LDH <14 days 310-1220 IU/L
>14 days - 1 yr 190-450 IU/L
>1-10 yrs 190-320 IU/L
>10-15 yrs 160-280 IU/L
>15-18 yrs 130-250 IU/L
>18 yrs 110-220 IU/L
LH <10 yrs 0-2.5 IU/L
>10-15 yrs 0-2.5 IU/L levels rise during puberty towards adult range
>15 (female)
Follicular 2-8 IU/L
Mid-Cycle 10-75 IU/L
Luteal 2-8 IU/L
Post-Menopausal >15 IU/L
Antenatal <1 IU/L
Male 2-9 IU/L
Lipase 10-70 U/L
Magnesium 0.6-1.2 mmol/L
Oestradiol Follicular 77-920 pmol/L
Mid-Cycle 140-2380 pmol/L
Luteal 77-1145 pmol/L
Post-Menopausal <103 pmol/L
Male <160 pmol/L
Osmolality 280-300 mosm/kg
Phosphate <30 days 1.3-2.5 mmol/L
30 days - 1 yr 1.2-2.2 mmol/L
>1-4 yrs 1.1-2.0 mmol/L
>4-11 yrs 1.0-2.0 mmol/L
>11-16 yrs 0.9-1.9 mmol/L
>16 yrs 0.8-1.5 mmol/L
Potassium 3.5-5.2 mmol/L
Progesterone Follicular 1-4 nmol/L
Luteal 15-100 nmol/L
Post-Menopausal <4 nmol/L
Male 0-1 nmol/L
Prolactin Female 25-630 mIU/L
Male 55-380 mIU/L
Protein (Total) <2 months 45/70 g/L
>2-12 months 50-80 g/L
>1-6 yrs 55/80 g/L
>6-11 yrs 60-83 g/L
>11 yrs 64-83 g/L
PSA <4.0 ug/L
PTH (Intact) 1.6-7.2 pmol/L
Rheumatoid Factor <30 IU/L
Sodium 135-145 mmol/L
Transferrin <2 months 1.3-2.3 g/L
>2 months - 3 yrs 1.6-3.3 g/L
>3 yrs 2.0-3.5 g/L
% Saturation Male 20-60 %
Female 20-50 %
hs-Troponin I Male 0-34 ng/L
Female 0-16 ng/L
TSH <4 days 1.0-20.0 mIU/L
4 days - 1 month 0.7-16.0 mIU/L
>1-6 months 0.5-6.0 mIU/L
>6 months 0.4-4.0 mIU/L
Free T4 4 days - <1 month 10-40 pmol/L
1 month - <1 yr 10-30 pmol/L
1-<12 yrs 11-22 pmol/L
12 yrs and above 12-22 pmol/L
Free T3 <12 months 4.5-10.5 pmol/L
1-12 yrs 3.8-8.6 pmol/L
>12-18 yrs 3.7-7.7 pmol/L
>18 yrs 2.5-6.0 pmol/L
Urea <1 month 1.1-6.1 mmol/L
>1 month - 2 yrs 0.7-5.0 mmol/L
>2-4 yrs 1.1-5.0 mmol/L
>4-6 yrs 1.1-5.7 mmol/L
>6-10 yrs 1.4-5.7 mmol/L
>10-13 yrs 1.8-6.4 mmol/L
>13 yrs 3.2-7.7 mmol/L
Uric Acid 0-12 yrs 0.08-0.34 mmol/L
>12 yrs (male) 0.20-0.42 mmol/L
>12 yrs (female) 0.15-0.36 mmol/L


BLODD GASES ARTERIAL VENOUS UNITS COMMENTS
pH 7.35-7.45 7.30-7.40
pCO2 35-45 40-50 mmHg
pO2 75-105 mmHg
Bicarbonate (HCO3) 22-28 22-32 mmol/L
Standard Bicarbonate 22-28 22-32 mmol/L
Base Excess (ABE) +/- 3 +/- 3 mmol/L
o2 Saturation 97-100 %
Carboxyhaemoglobin (COHb) 0-1.5 (non-smoker) 0-1.5 (non-smoker) %
<9 (smoker) <9 (smoker) %
MetHb 0-1.5 0-1.5 %
Sodium 135-145 135-145 mmol/L
Potassium 3.5-5.2 3.5-5.2 mmol/L
Ionised Calcium 1.15-1.30 1.15-1.30 mmol/L
Ionised Calcium - corrected (pH 7.4) 1.13-1.26 1.13-1.26 mmol/L
Chloride 95-110 95-110 mmol/L
Glucose (random) 3.5-7.7 3.5-7.7 mmol/L
Lactate <2.0 <2.0 mmol/L
Anion Gap 10-20 10-20 mmol/L
CORD GASES ARTERIAL VENOUS UNITS COMMENTS
pH 7.10-7.40 7.22-7.44
pCO2 42-74 28-53 mmHg
pO2 6-28 16-40 mmHg
HCO3 18-28 17-26 mmol/L
Base Excess -12 to +2 -12 to +2 mmol/L
Lactate <6.1 <6.1 mmol/L


Urine SEX/AGE REF RANGE UNITS COMMENTS
U Calcium (24hrs) 2.5-7.5 mmol/24hrs
U Creatinine (24hrs) 0-6 months 0.2-1.6 mmol/24hrs
>6 months - 2 yrs 0.2-2.0 mmol/24hrs
>2-6 yrs 0.5-6.0 mmol/24hrs
>6-10 yrs 1.5-12.6 mmol/24hrs
>10-15 yrs 2.0-20.0 mmol/24hrs
>15 yrs (male) 9.0-18.0 mmol/24hrs
>15 yrs (female) 7.0-12.5 mmol/24hrs
Creatinine Clearance >1.5 ml/sec
U Albumin <30 mg/L
U Alb/Crn Ratio Male <2.5 g(alb)/mol(Crn)
Female <3.5 g(alb)/mol(Crn)
U Osmolality 0-6 yrs 50-1200 mosm/kg
>6 yrs 300-1200 mosm/kg
U pH 5-8.8
U Phosphate (24hrs) 16-48 mmol/24hrs dependent on diet, age, muscle mass
U Potassium (24hrs) 35-100 mmol/24hrs diet dependent
U Protein (24hrs) 0.0-0.14 g/24hrs
U Pro/Crn Ratio <22.7 g/mol
U Sodium (24hrs) 100-250 mmol/24hrs diet dependent
U Urea (24hrs) 165-580 mmol/24hrs


LIPIDS SEX/AGE REF RANGE UNITS COMMENTS
Cholesterol (Total) <4.0 mmol/L
HDL Cholesterol >1.0 mmol/L
LDL (calculated) <2.5 mmol/L
Chol/HDL Ratio <4.5
Triglyceride <1.7 mmol/L

Optimal lipid levels are suggested by the New Zealand Guidelines Group. http://www.health.govt.nz/publication/new-zealand-primary-care-handbook-2012


DRUGS REF RANGE UNITS COMMENTS
Carbamazepine Therapeutic range 16-50 umol/L
Digoxin Therapeutic range 0.6-2.0 nmol/L >6 hrs post-dose
Ethanol Nil detected <2.2 mmol/L
Lithium for prophylaxis 0.4-0.8 mmol/L
for acute mania 0.8-1.2 mmol/L
toxicity is common >1.2 mmol/L >12 hrs post-dose
Phenytoin Therapeutic range 40-80 umol/L
Salicylate Therapeutic range 1.5-1.8 mmol/L
Toxic >3.6 mmol/L
Theophylline Therapeutic range 55-110 umol/L
Valproate <6 months 28-55 umol/L
>6 months 350-700 umol/L not reported but widely accepted as a trough range

Note: Antibiotics - Gentamicin, Vancomycin and Tobramycin ranges, please refer to Pharmacy for dose and time related reference ranges.


Reference ranges have been set in agreeance with: - The South Island Quality Assurance Group (SIQAG) - Chemical Pathology Network New Zealand (CHEMPNNZ) - Te Whatu Ora Hawkes Bay Chemical Pathologist - Abbott Alinity assay specific reference ranges - The LabNet Delphic Partners


Reference ranges reviewed August 2023

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