Cgreenwo: Created page with " {| class="wikitable" | '''Drug''' |'''Ideal Sampling Time¹''' |'''Minimum resampling interval²''' |- |'''AMINOGLYCOSIDES''' (Gentamicin and Tobramycin) |'''Conventional Dosing (e.g. 3x day)''' '''Trough: <'''30 minutes before dose '''Peak: ''' 1 hour after IM injection or 1 hour after start IV infusion | 1 day |- | |'''Once daily dosing (ODD)''' '''Trough: ''' 18 hours after dose (or refer to specific ODD guidelines / contact..."

2022-08-04T23:42:11Z

Created page with " {| class="wikitable" | '''Drug''' |'''Ideal Sampling Time1''' |'''Minimum resampling interval2''' |- |'''AMINOGLYCOSIDES''' (Gentamicin and Tobramycin) |'''Conventional Dosing (e.g. 3x day)''' '''Trough: <'''30 minutes before dose '''Peak: ''' 1 hour after IM injection or 1 hour after start IV infusion | 1 day |- | |'''Once daily dosing (ODD)''' '''Trough: ''' 18 hours after dose (or refer to specific ODD guidelines / contact..."

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{| class="wikitable"
| '''Drug'''
|'''Ideal Sampling Time1'''
|'''Minimum resampling interval2'''
|-
|'''AMINOGLYCOSIDES''' (Gentamicin and Tobramycin)
|'''Conventional Dosing (e.g. 3x day)'''

'''Trough: <'''30 minutes before dose

'''Peak: ''' 1 hour after IM injection or 1 hour after start IV infusion
|

1 day
|-
|
|'''Once daily dosing (ODD)'''

'''Trough: ''' 18 hours after dose (or refer to specific ODD guidelines / contact Pharmacy for time of trough.)

'''Peak: ''' 1 hour after start IV infusion
|

A sample can be taken on the first dose.
|-
|'''CARBAMAZEPINE'''

(Tegretol)
|Immediately before an oral dose
|Initiation of therapy: 2-4 weeks.

Chronic therapy:

4 days.
|-
|'''DIGOXIN'''
|At least 6-8 hours after OR immediately before an IV or oral dose
|7 days
|-
|'''LITHIUM'''
|At 12 hours after dose
|Check weekly until stable, then 2-3 monthly.
|-
|'''PHENYTOIN'''

(Dilantin)
|> 6 hours post dose OR immediately before an oral dose
|Dose dependent, 2-4 weeks.
|-
|'''THEOPHYLLINE'''

(Nuelin, Aminophylline)
|'''ORAL''' (slow release preparation) 4-8 hours after dose OR Immediately before a dose

'''IV''' (continuous infusion) sample at 12 and 24 hours
|2 days
|-
|'''VALPROATE SODIUM'''

(Epilim, Valproic acid)
|> 6 hours post dose OR immediately before an oral dose
|3 days
|-
|'''VANCOMYCIN'''
|'''Trough:''' Immediately before an IV dose

'''Peak: ''' Not necessary
|1-2 days
|}
'''1. Ideal Sampling Time:''' This should be adhered to wherever possible. Drug levels taken at these times provide more meaningful information and this facilitates the interpretation of results.

'''2. Minimum resampling intervals:''' This is the earliest time a drug level should be measured following initiation of therapy or a change of dosage (unless therapeutic failure or toxicity is suspected). These times are based on the average time to steady state.

'''References:'''

'''''Abbott package insert.'''''

'''''Tietz, "Textbook of Clinical Chemistry and Molecular Diagnostics", 5th edition.'''''

'''''Medicine - Therapeutic Monitoring - IVTG002 HBDHB IV & Therapeutic Guidelines, July 2019.'''''

Drug Level Sampling Times - Revision history